Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.

The efficacy of an antibody-drug conjugate (ADC) is dependent on the properties of its linker-payload which must remain stable while in systemic circulation but undergo efficient processing upon internalization into target cells. Here, we examine the stability of a non-cleavable Amino-PEG6-based lin...

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Bibliographic Details
Main Authors: Magdalena Dorywalska, Pavel Strop, Jody A Melton-Witt, Adela Hasa-Moreno, Santiago E Farias, Meritxell Galindo Casas, Kathy Delaria, Victor Lui, Kris Poulsen, Janette Sutton, Gary Bolton, Dahui Zhou, Ludivine Moine, Russell Dushin, Thomas-Toan Tran, Shu-Hui Liu, Mathias Rickert, Davide Foletti, David L Shelton, Jaume Pons, Arvind Rajpal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4498778?pdf=render

Internet

http://europepmc.org/articles/PMC4498778?pdf=render

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