Characterization of the HCMV-Specific CD4 T Cell Responses that Are Associated with Protective Immunity

Characterization of the HCMV-Specific CD4 T Cell Responses that Are Associated with Protective Immunity

Most humans become infected with human cytomegalovirus (HCMV). Typically, the immune system controls the infection, but the virus persists and can reactivate in states of immunodeficiency. While substantial information is available on the contribution of CD8 T cells and antibodies to anti-HCMV immun...

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Bibliographic Details
Main Authors: Marie Wunsch, Wenji Zhang, Jodi Hanson, Richard Caspell, Alexey Y. Karulin, Mascha S. Recks, Stefanie Kuerten, Srividya Sundararaman, Paul V. Lehmann
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Viruses
Subjects:
Human cytomegalovirus (HCMV)
Enzyme-Linked Immunospot assay (ELISPOT)
CD4 T cells
cytokine secretion
kinetics
Online Access:http://www.mdpi.com/1999-4915/7/8/2828

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http://www.mdpi.com/1999-4915/7/8/2828

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