Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity

Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity

Mesenchymal stromal cells (MSCs) are inherently immunomodulatory through production of inhibiting soluble factors and expression of immunosuppressive cell surface markers. We tested whether activated MSCs qualify for the induction of antigen-specific immune regulation. Bone marrow derived human MSCs...

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Bibliographic Details
Main Authors: Kayleigh M. van Megen, Ernst-Jan T. van 't Wout, Julia Lages Motta, Bernice Dekker, Tatjana Nikolic, Bart O. Roep
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
immune regulation
type 1 diabetes (T1D)
antigen specific
immunotherapy
mesenchymal stromal cell (MSC)
antigen presenting cell (APC)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00694/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00694/full

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