Crosstalk between Human Microvascular Endothelial Cells and Tubular Epithelial Cells Modulates Pro-Inflammatory Responses Induced by Shiga Toxin Type 2 and Subtilase Cytotoxin

Crosstalk between Human Microvascular Endothelial Cells and Tubular Epithelial Cells Modulates Pro-Inflammatory Responses Induced by Shiga Toxin Type 2 and Subtilase Cytotoxin

Hemolytic uremic syndrome (HUS) is a consequence of Shiga toxin (Stx)-producing Escherichia coli (STEC) infection and is the most frequent cause of acute renal failure (ARF) in children. Subtilase cytotoxin (SubAB) has also been associated with HUS pathogenesis. We previously reported that Stx2 and...

Full description

Bibliographic Details
Main Authors: Romina S. Álvarez, Carolina Jancic, Nicolás Garimano, Flavia Sacerdoti, Adrienne W. Paton, James C. Paton, Cristina Ibarra, María M. Amaral
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Toxins
Subjects:
shiga toxin
subtilase cytotoxin
hemolytic uremic syndrome
endothelial/epithelial human renal cells
co-cultures
cytokines
Online Access:https://www.mdpi.com/2072-6651/11/11/648

Internet

https://www.mdpi.com/2072-6651/11/11/648

Similar Items