Aryl hydrocarbon receptor (AhR)-mediated perturbations in gene expression during early stages of CD4+ T-cell differentiation

Aryl hydrocarbon receptor (AhR)-mediated perturbations in gene expression during early stages of CD4+ T-cell differentiation

Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates potent suppression of T-cell dependent immune responses. The suppressive effects of TCDD occur early during CD4+ T-cell differentiation in the absence of effects on prolif...

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Bibliographic Details
Main Authors: Diana eRohlman, Duy ePham, Zhen eYu, Linda B. Steppan, Nancy I. Kerkvliet
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Immunology
Subjects:
Gene Expression
2
7
Aryl hydrocarbon receptor
IL-22
3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00223/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00223/full

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