Aryl hydrocarbon receptor (AhR)-mediated perturbations in gene expression during early stages of CD4+ T-cell differentiation

by Diana eRohlman, Duy ePham, Zhen eYu, Linda B. Steppan, Nancy I. Kerkvliet, Nancy I. Kerkvliet
Published 2012-08-01

A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain

by Arden Perkins, Jessica L. Phillips, Nancy I. Kerkvliet, Robert L. Tanguay, Gary H. Perdew, Siva K. Kolluri, William H. Bisson
Published 2014-10-01

Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice

by Heather M. Kahalehili, Nolan K. Newman, Jamie M. Pennington, Siva K. Kolluri, Nancy I. Kerkvliet, Natalia Shulzhenko, Andrey Morgun, Allison K. Ehrlich
Published 2021-01-01

The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.

by Edmond F O'Donnell, Prasad Rao Kopparapu, Daniel C Koch, Hyo Sang Jang, Jessica Lynne Phillips, Robert L Tanguay, Nancy I Kerkvliet, Siva Kumar Kolluri
Published 2012-01-01

Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.

by Sumit Punj, Prasad Kopparapu, Hyo Sang Jang, Jessica L Phillips, Jamie Pennington, Diana Rohlman, Edmond O'Donnell, Patrick L Iversen, Siva Kumar Kolluri, Nancy I Kerkvliet
Published 2014-01-01

Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells

by Hyo Sang Jang, Martin Pearce, Edmond F. O’Donnell, Bach Duc Nguyen, Lisa Truong, Monica J. Mueller, William H. Bisson, Nancy I. Kerkvliet, Robert L. Tanguay, Siva Kumar Kolluri
Published 2017-12-01

The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.

by Edmond F O'Donnell, Katerine S Saili, Daniel C Koch, Prasad R Kopparapu, David Farrer, William H Bisson, Lijoy K Mathew, Sumitra Sengupta, Nancy I Kerkvliet, Robert L Tanguay, Siva Kumar Kolluri
Published 2010-10-01