Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System

Chemokines have two types of interactions that function cooperatively to control cell migration. Chemokine receptors on migrating cells integrate signals initiated upon chemokine binding to promote cell movement. Interactions with glycosaminoglycans (GAGs) localize chemokines on and near cell surfac...

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Bibliographic Details
Main Authors: Amanda E. I. Proudfoot, Zoë Johnson, Pauline Bonvin, Tracy M. Handel
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/10/3/70