Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System

by Amanda E. I. Proudfoot, Zoë Johnson, Pauline Bonvin, Tracy M. Handel
Published 2017-08-01

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.

by Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva
Published 2020-04-01

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization

by Douglas P. Dyer, Elisa Migliorini, Catherina L. Salanga, Dhruv Thakar, Tracy M. Handel, Ralf P. Richter
Published 2017-01-01

Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis.

by Morgan O'Hayre, Catherina L Salanga, Thomas J Kipps, Davorka Messmer, Pieter C Dorrestein, Tracy M Handel
Published 2010-07-01

Structural basis of ligand interaction with atypical chemokine receptor 3

by Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel
Published 2017-01-01

A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling

by Neil J. Grimsey, Rachan Narala, Cara C. Rada, Sohum Mehta, Bryan S. Stephens, Irina Kufareva, John Lapek, David J. Gonzalez, Tracy M. Handel, Jin Zhang, JoAnn Trejo
Published 2018-09-01

A general method for site specific fluorescent labeling of recombinant chemokines.

by Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin, Michael R Dores, Thomas H Smith, Neil Grimsey, Ruben Abagyan, Joann Trejo, Irina Kufareva, Mark M Fuster, Catherina L Salanga, Tracy M Handel
Published 2014-01-01

Cytokines and growth factors cross-link heparan sulfate

by Elisa Migliorini, Dhruv Thakar, Jens Kühnle, Rabia Sadir, Douglas P. Dyer, Yong Li, Changye Sun, Brian F. Volkman, Tracy M. Handel, Liliane Coche-Guerente, David G. Fernig, Hugues Lortat-Jacob, Ralf P. Richter
Published 2015-01-01

MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma

by Philipp Wiesner, Maria Tafelmeier, Dominik Chittka, Soo-Ho Choi, Li Zhang, Young Sup Byun, Felicidad Almazan, Xiaohong Yang, Navaid Iqbal, Punam Chowdhury, Alan Maisel, Joseph L. Witztum, Tracy M. Handel, Sotirios Tsimikas, Yury I. Miller
Published 2013-07-01