SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.

SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.

Enteric bacterial pathogens such as enterohemorrhagic E. coli (EHEC) and Salmonella Typhimurium target the intestinal epithelial cells (IEC) lining the mammalian gastrointestinal tract. Despite expressing innate Toll-like receptors (TLRs), IEC are innately hypo-responsive to most bacterial products....

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Bibliographic Details
Main Authors: Ho Pan Sham, Emily Yi Shan Yu, Muhammet F Gulen, Ganive Bhinder, Martin Stahl, Justin M Chan, Lara Brewster, Vijay Morampudi, Deanna L Gibson, Michael R Hughes, Kelly M McNagny, Xiaoxia Li, Bruce A Vallance
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3738496?pdf=render

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http://europepmc.org/articles/PMC3738496?pdf=render

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