Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction.

by Andrea Hodgson, Eric M Wier, Kai Fu, Xin Sun, Hongbing Yu, Wenxin Zheng, Ho Pan Sham, Kaitlin Johnson, Scott Bailey, Bruce A Vallance, Fengyi Wan
Published 2015-03-01

A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection.

by Martin Stahl, Jenna Ries, Jenny Vermeulen, Hong Yang, Ho Pan Sham, Shauna M Crowley, Yuliya Badayeva, Stuart E Turvey, Erin C Gaynor, Xiaoxia Li, Bruce A Vallance
Published 2014-07-01

Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

by Kirk S B Bergstrom, Vanessa Kissoon-Singh, Deanna L Gibson, Caixia Ma, Marinieve Montero, Ho Pan Sham, Natasha Ryz, Tina Huang, Anna Velcich, B Brett Finlay, Kris Chadee, Bruce A Vallance
Published 2010-05-01

Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation.

by Kirk S B Bergstrom, Vijay Morampudi, Justin M Chan, Ganive Bhinder, Jennifer Lau, Hyungjun Yang, Caixia Ma, Tina Huang, Natasha Ryz, Ho Pan Sham, Maryam Zarepour, Colby Zaph, David Artis, Meera Nair, Bruce A Vallance
Published 2015-08-01

SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.

by Ho Pan Sham, Emily Yi Shan Yu, Muhammet F Gulen, Ganive Bhinder, Martin Stahl, Justin M Chan, Lara Brewster, Vijay Morampudi, Deanna L Gibson, Michael R Hughes, Kelly M McNagny, Xiaoxia Li, Bruce A Vallance
Published 2013-01-01

Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis

by Ho Pan Sham, Mark Bazett, Momir Bosiljcic, Hyungjun Yang, Beryl Luk, Hong T. Law, Hong T. Law, Vijay Morampudi, Hong B. Yu, Jim Pankovich, Simon Sutcliffe, Brian Bressler, John K. Marshall, Richard N. Fedorak, Jenny Chen, Michelle Jones, Hal Gunn, Shirin Kalyan, Shirin Kalyan, Bruce A. Vallance
Published 2018-09-01