Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer

Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer

B7-H4, an immune suppressive member of the B7 family, is highly expressed in a wide variety of human malignancies making it an attractive immunotherapeutic target. However, the association between B7-H4 expression in the tumor microenvironment and the immune infiltrate has not been comprehensively e...

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Bibliographic Details
Main Authors: Heather L. MacGregor, Carlos Garcia-Batres, Azin Sayad, Andrew Elia, Hal K. Berman, Aras Toker, Sarah Rachel Katz, Patricia A. Shaw, Blaise A. Clarke, Sarah Q. Crome, Celine Robert-Tissot, Marcus Q. Bernardini, Linh T. Nguyen, Pamela S. Ohashi
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:OncoImmunology
Subjects:
b7-h4
epithelial ovarian cancer
cxcl17
immune infiltration
tumor infiltration
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1665460

Internet

http://dx.doi.org/10.1080/2162402X.2019.1665460

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