Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells

Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells

We previously reported that raloxifene, an estrogen receptor modulator, is also a ligand for the aryl hydrocarbon receptor (AhR). Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. We performed structure–activity studies with seven raloxifene analogs to be...

Full description

Bibliographic Details
Main Authors: Hyo Sang Jang, Martin Pearce, Edmond F. O’Donnell, Bach Duc Nguyen, Lisa Truong, Monica J. Mueller, William H. Bisson, Nancy I. Kerkvliet, Robert L. Tanguay, Siva Kumar Kolluri
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Biology
Subjects:
aryl hydrocarbon receptor
raloxifene
Y134
estrogen receptor modulator
hepatoma
agonist
antagonist
anti-cancer drug
triple negative breast cancer
apoptosis
Online Access:https://www.mdpi.com/2079-7737/6/4/41

Internet

https://www.mdpi.com/2079-7737/6/4/41

Similar Items