Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...

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Bibliographic Details
Main Authors: Yukiko Miyazaki, Daniel K. Inaoka, Tomoo Shiba, Hiroyuki Saimoto, Takaya Sakura, Eri Amalia, Yasutoshi Kido, Chika Sakai, Mari Nakamura, Anthony L. Moore, Shigeharu Harada, Kiyoshi Kita
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
pyrimidine de novo biosynthesis
ubiquinone binding-site inhibitor
tumor bioenergetics
tumor microenvironment
structure–activity relationship
anticancer activity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00997/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00997/full

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