X-Ray snapshots of a pyridoxal enzyme: a catalytic mechanism involving concerted [1,5]-hydrogen sigmatropy in methionine γ-lyase

by Dan Sato, Tomoo Shiba, Tsuyoshi Karaki, Wataru Yamagata, Tomoyoshi Nozaki, Takashi Nakazawa, Shigeharu Harada
Published 2017-07-01

Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella

by Makoto Matsubayashi, Daniel Ken Inaoka, Keisuke Komatsuya, Takeshi Hatta, Fumiya Kawahara, Kimitoshi Sakamoto, Kenji Hikosaka, Junya Yamagishi, Kazumi Sasai, Tomoo Shiba, Shigeharu Harada, Naotoshi Tsuji, Kiyoshi Kita
Published 2019-01-01

Structural and Biochemical Features of <i>Eimeria tenella</i> Dihydroorotate Dehydrogenase, a Potential Drug Target

by Dan Sato, Endah Dwi Hartuti, Daniel Ken Inaoka, Takaya Sakura, Eri Amalia, Madoka Nagahama, Yukina Yoshioka, Naotoshi Tsuji, Tomoyoshi Nozaki, Kiyoshi Kita, Shigeharu Harada, Makoto Matsubayashi, Tomoo Shiba
Published 2020-12-01

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

by Daniel Ken Inaoka, Tomoo Shiba, Dan Sato, Emmanuel Oluwadare Balogun, Tsuyoshi Sasaki, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Junko Ohmori, Teruki Honma, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
Published 2015-07-01

Identification of <i>Plasmodium falciparum</i> Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box

by Xinying Wang, Yukiko Miyazaki, Daniel Ken Inaoka, Endah Dwi Hartuti, Yoh-Ichi Watanabe, Tomoo Shiba, Shigeharu Harada, Hiroyuki Saimoto, Jeremy Nicholas Burrows, Francisco Javier Gamo Benito, Tomoyoshi Nozaki, Kiyoshi Kita
Published 2019-06-01

Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method.

by Ryunosuke Yoshino, Nobuaki Yasuo, Daniel Ken Inaoka, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Tomoo Shiba, Shigeharu Harada, Teruki Honma, Emmanuel Oluwadare Balogun, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Kiyoshi Kita, Masakazu Sekijima
Published 2015-01-01

Identification of 3,4-Dihydro-2<i>H</i>,6<i>H</i>-pyrimido[1,2-<i>c</i>][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of <i>Plasmodium falciparum</i> Dihydroo...

by Endah Dwi Hartuti, Takaya Sakura, Mohammed S. O. Tagod, Eri Yoshida, Xinying Wang, Kota Mochizuki, Rajib Acharjee, Yuichi Matsuo, Fuyuki Tokumasu, Mihoko Mori, Danang Waluyo, Kazuro Shiomi, Tomoyoshi Nozaki, Shinjiro Hamano, Tomoo Shiba, Kiyoshi Kita, Daniel Ken Inaoka
Published 2021-07-01

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

by Yukiko Miyazaki, Yukiko Miyazaki, Daniel K. Inaoka, Daniel K. Inaoka, Daniel K. Inaoka, Tomoo Shiba, Hiroyuki Saimoto, Takaya Sakura, Eri Amalia, Yasutoshi Kido, Chika Sakai, Mari Nakamura, Anthony L. Moore, Shigeharu Harada, Kiyoshi Kita, Kiyoshi Kita, Kiyoshi Kita
Published 2018-09-01

The Open Form Inducer Approach for Structure-Based Drug Design.

by Daniel Ken Inaoka, Maiko Iida, Toshiyuki Tabuchi, Teruki Honma, Nayoung Lee, Satoshi Hashimoto, Shigeru Matsuoka, Takefumi Kuranaga, Kazuhito Sato, Tomoo Shiba, Kimitoshi Sakamoto, Emmanuel Oluwadare Balogun, Shigeo Suzuki, Takeshi Nara, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Akiko Tanaka, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
Published 2016-01-01