Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone

Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone

Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT. We showed that knockdown of Hsp70 reduced cell mi...

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Bibliographic Details
Main Authors: Alina D. Nikotina, Snezhana A. Vladimirova, Elena Y. Komarova, Dmitry Alexeev, Sergey Efremov, Elizaveta Leonova, Rostislav Pavlov, Viktor G. Kartsev, Sergey G. Polonik, Boris A. Margulis, Irina V. Guzhova
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
colon cancer
hyperglycemia
EMT
Hsp70
CL-43
PES
Online Access:https://www.mdpi.com/1422-0067/22/13/6902

Internet

https://www.mdpi.com/1422-0067/22/13/6902

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