Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.

Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.

Genetic and environmental factors influence susceptibility to Crohn's disease (CD): NOD2 is the strongest individual genetic determinant and smoking the best-characterised environmental factor. Carriage of NOD2 mutations predispose to small-intestinal, stricturing CD, a phenotype also associate...

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Bibliographic Details
Main Authors: Marian C Aldhous, Kimberley Soo, Lesley A Stark, Agata A Ulanicka, Jennifer E Easterbrook, Malcolm G Dunlop, Jack Satsangi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3171477?pdf=render

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http://europepmc.org/articles/PMC3171477?pdf=render

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