ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.

ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.

CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune functions. CD47-SIRPα signaling has also been implicated in...

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Bibliographic Details
Main Authors: Steven E Kauder, Tracy C Kuo, Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Sony S Rocha, Sangeetha Bollini, Bora Han, Janet Sim, Jaume Pons, Hong I Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6104973?pdf=render

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http://europepmc.org/articles/PMC6104973?pdf=render

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