615 Targeted immune cell activation by systemic delivery of toll-like receptor 9 agonist antibody conjugates induce potent anti-tumor immunity

by Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Danielle Fontaine, Bora Han, Curt Bradshaw, Jaume Pons, Janet Sim, Tracy Kuo, Hong Wan
Published 2020-11-01

ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.

by Steven E Kauder, Tracy C Kuo, Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Sony S Rocha, Sangeetha Bollini, Bora Han, Janet Sim, Jaume Pons, Hong I Wan
Published 2018-01-01

Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

by Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan
Published 2020-11-01