No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial [version 1; peer review: 2 approved]

Background: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity. The WOMAN trial showed that tranexamic acid (TXA) reduces death due to bleeding in women with PPH. To determine whether TXA has pro-thrombotic effects in women with PPH, we measured endogenous thrombin po...

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Bibliographic Details
Main Authors: Kastriot Dallaku, Haleema Shakur-Still, Danielle Beaumont, Ian Roberts, Sumaya Huque, Maria Delius, Stefan Holdenrieder, Orion Gliozheni, Ulrich Mansmann
Format: Article
Language:English
Published: Wellcome 2019-02-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/4-21/v1