Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2<i>H</i>-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2<i>H</i>-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor

In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2<i>H</i>-benzo[d]imidazole-2-one substructure pres...

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Bibliographic Details
Main Authors: Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
NLRP3 inhibitors
pyroptosis
interleukin-1β
ATP hydrolysis
MD simulations
Online Access:https://www.mdpi.com/1420-3049/26/13/3975

Internet

https://www.mdpi.com/1420-3049/26/13/3975

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