Phenotypic characterization of a novel virulence-factor deletion strain of Burkholderia mallei that provides partial protection against inhalational glanders in mice

Phenotypic characterization of a novel virulence-factor deletion strain of Burkholderia mallei that provides partial protection against inhalational glanders in mice

Burkholderia mallei (Bm) is a highly infectious intracellular pathogen classified as a category B biological agent by the Centers for Disease Control and Prevention. After respiratory exposure, Bm establishes itself within host macrophages before spreading into major organ systems, which can lead to...

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Bibliographic Details
Main Authors: Joel A. Bozue, Sidhartha eChaudhury, Kei eAmemiya, Jennifer eChua, Christopher K. Cote, Ronald G. Toothman, Jennifer L. Dankmeyer, Christopher P. Klimko, Catherine L. Wilhelmsen, Jolynn W. Raymond, Nela eZavaljevski, Jaques eReifman, Anders eWallqvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Burkholderia mallei
Glanders
aerosol
virulence factor
Live-attenuated vaccine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00021/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00021/full

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