EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.

Bibliographic Details
Main Authors: Wendy Béguelin, Martín A. Rivas, María T. Calvo Fernández, Matt Teater, Alberto Purwada, David Redmond, Hao Shen, Matt F. Challman, Olivier Elemento, Ankur Singh, Ari M. Melnick
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01029-x

Internet

https://doi.org/10.1038/s41467-017-01029-x

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