Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KATP channels through CaMKII activation

Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KATP channels through CaMKII activation

Abstract Background Cardiac Ca2+/calmodulin-dependent protein kinase II (CaMKII) activation plays a critical role in cardiomyocyte (CM) apoptosis and arrhythmia. Functional ATP-sensitive potassium (KATP) channels are essential for cardiac protection during ischemia. In cultured CMs, L5 low-density l...

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Bibliographic Details
Main Authors: Yanzhuo Ma, Nancy Cheng, Junping Sun, Jonathan Xuhai Lu, Shahrzad Abbasi, Geru Wu, An-Sheng Lee, Tatsuya Sawamura, Jie Cheng, Chu-Huang Chen, Yutao Xi
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Lipids in Health and Disease
Subjects:
Action potential
ATP-sensitive potassium
Ca2+/calmodulin-dependent protein kinase II
Cardiomyocytes
Electronegative low-density lipoprotein
Online Access:http://link.springer.com/article/10.1186/s12944-020-01368-7

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http://link.springer.com/article/10.1186/s12944-020-01368-7

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