Nasal Immunization with the C-Terminal Domain of Bcla3 Induced Specific IgG Production and Attenuated Disease Symptoms in Mice Infected with <i>Clostridioides difficile</i> Spores

Nasal Immunization with the C-Terminal Domain of Bcla3 Induced Specific IgG Production and Attenuated Disease Symptoms in Mice Infected with <i>Clostridioides difficile</i> Spores

<i>Clostridioides difficile</i> is a Gram-positive, spore-forming bacterium that causes a severe intestinal infection. Spores of this pathogen enter in the human body through the oral route, interact with intestinal epithelial cells and persist in the gut. Once germinated, the vegetative...

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Bibliographic Details
Main Authors: Ana Raquel Maia, Rodrigo Reyes-Ramírez, Marjorie Pizarro-Guajardo, Anella Saggese, Ezio Ricca, Loredana Baccigalupi, Daniel Paredes-Sabja
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
mucosal vaccine
exosporium proteins
<i>Bacillus subtilis</i>
immune response
<i>Clostridium difficile</i>
gastrointestinal infection
Online Access:https://www.mdpi.com/1422-0067/21/18/6696

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https://www.mdpi.com/1422-0067/21/18/6696

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