L1 Cell Adhesion Molecule Confers Radioresistance to Ovarian Cancer and Defines a New Cancer Stem Cell Population

L1 Cell Adhesion Molecule Confers Radioresistance to Ovarian Cancer and Defines a New Cancer Stem Cell Population

Many solid tumors, including ovarian cancer, contain small populations of cancer stem cells (CSCs). These cells are usually resistant against conventional cancer therapies and play a role in disease recurrence. We demonstrated that the L1 cell adhesion molecule (L1CAM) is a new CSC target in ovarian...

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Bibliographic Details
Main Authors: Nastassja Terraneo, Francis Jacob, Claudia Peitzsch, Anna Dubrovska, Christiane Krudewig, Yen-Lin Huang, Viola Heinzelmann-Schwarz, Roger Schibli, Martin Béhé, Jürgen Grünberg
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
l1 cell adhesion molecule
ovarian cancer
stem cells
radioresistance
crispr-cas9
epithelial-to-mesenchymal transition
Online Access:https://www.mdpi.com/2072-6694/12/1/217

Internet

https://www.mdpi.com/2072-6694/12/1/217

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