Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Metastatic cells can mimic many of the phenotypic behaviors of embryonic cells. Here, the authors generate a melanoblast-specific transcriptome using a genetically engineered mouse model and identify KDELR3 as a pro-metastasis gene in melanoma.

Bibliographic Details
Main Authors: Kerrie L. Marie, Antonella Sassano, Howard H. Yang, Aleksandra M. Michalowski, Helen T. Michael, Theresa Guo, Yien Che Tsai, Allan M. Weissman, Maxwell P. Lee, Lisa M. Jenkins, M. Raza Zaidi, Eva Pérez-Guijarro, Chi-Ping Day, Kris Ylaya, Stephen M. Hewitt, Nimit L. Patel, Heinz Arnheiter, Sean Davis, Paul S. Meltzer, Glenn Merlino, Pravin J. Mishra
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14085-2

Internet

https://doi.org/10.1038/s41467-019-14085-2

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