Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc/KRAS-mutant intestinal tumours. Whereas CSCs ar...

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Bibliographic Details
Main Authors: Mehrnaz Ghazvini, Petra Sonneveld, Andreas Kremer, Patrick Franken, Andrea Sacchetti, Yaser Atlasi, Sabrina Roth, Rosalie Joosten, Ron Smits, Riccardo Fodde
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3775784?pdf=render

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http://europepmc.org/articles/PMC3775784?pdf=render

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