Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal recessive parkinsonism. Remarkably, Parkin can prot...

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Bibliographic Details
Main Authors: Grace G Y Lim, Katherine C M Chew, Xiao-Hui Ng, Adeline Henry-Basil, Roy W X Sim, Jeanne M M Tan, Chou Chai, Kah-Leong Lim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3759450?pdf=render

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http://europepmc.org/articles/PMC3759450?pdf=render

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