Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice

Objective: The Notch family of intermembrane receptors is highly conserved across species and is involved in cell fate and lineage control. Previous in vitro studies have shown that Notch may inhibit adipogenesis. Here we describe the role of Notch in adipose tissue by employing an in vivo murine mo...

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Bibliographic Details
Main Authors: Dionysios V. Chartoumpekis, Dushani L. Palliyaguru, Nobunao Wakabayashi, Nicholas K.H. Khoo, Gabriele Schoiswohl, Robert M. O'Doherty, Thomas W. Kensler
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Molecular Metabolism
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000769