Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Abstract Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferr...

Full description

Bibliographic Details
Main Authors: Johannes Steffen, Markus Krohn, Christina Schwitlick, Thomas Brüning, Kristin Paarmann, Claus U. Pietrzik, Henrik Biverstål, Baiba Jansone, Oliver Langer, Jens Pahnke
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Acta Neuropathologica Communications
Subjects:
Murine amyloid-beta
Abeta
Transgenic mice
Amyloid precursor protein
Alzheimer’s disease
Amyloidosis
Online Access:http://link.springer.com/article/10.1186/s40478-017-0448-2

Similar Items

Similar Items