Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic

Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic

Summary: There is an urgent need for inexpensive new technologies that enable fast, reliable, and scalable detection of viruses. Here, we repurpose the type III CRISPR-Cas system for sensitive and sequence-specific detection of SARS-CoV-2. RNA recognition by the type III CRISPR complex triggers Cas1...

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Bibliographic Details
Main Authors: Andrew Santiago-Frangos, Laina N. Hall, Anna Nemudraia, Artem Nemudryi, Pushya Krishna, Tanner Wiegand, Royce A. Wilkinson, Deann T. Snyder, Jodi F. Hedges, Calvin Cicha, Helen H. Lee, Ava Graham, Mark A. Jutila, Matthew P. Taylor, Blake Wiedenheft
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports Medicine
Subjects:
CRISPR-Cas
type III
SARS-CoV-2
viral diagnostics
CRISPR Dx
COVID-19
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001622

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http://www.sciencedirect.com/science/article/pii/S2666379121001622

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