Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer

Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local radiation. Unfortunately, once metastatic, no available therapy is curative. The vast majority will die despite aggressive systemic combinational androgen-ablation therapies. Thus, there is an...

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Bibliographic Details
Main Authors: Emmanuel S. Akinboye, W. Nathaniel Brennen, Samuel R. Denmeade, John T. Isaacs
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Asian Journal of Urology
Online Access:http://www.sciencedirect.com/science/article/pii/S2214388218300924