Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

Pore-forming toxins (PFTs) constitute the single largest class of proteinaceous bacterial virulence factors and are made by many of the most important bacterial pathogens. Host responses to these toxins are complex and poorly understood. We find that the endoplasmic reticulum unfolded protein respon...

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Bibliographic Details
Main Authors: Larry J Bischof, Cheng-Yuan Kao, Ferdinand C O Los, Manuel R Gonzalez, Zhouxin Shen, Steven P Briggs, F Gisou van der Goot, Raffi V Aroian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18846208/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18846208/?tool=EBI

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