The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist.

by Yan Hu, Shu-Hua Xiao, Raffi V Aroian
Published 2009-08-01

Neuronal Goα and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins.

by Ferdinand C O Los, Christine Ha, Raffi V Aroian
Published 2013-01-01

Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice.

by Yan Hu, Sophia B Georghiou, Alan J Kelleher, Raffi V Aroian
Published 2010-03-01

A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection.

by Jason B Noon, Erich M Schwarz, Gary R Ostroff, Raffi V Aroian
Published 2019-04-01

Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.

by Audrey Bellier, Chang-Shi Chen, Cheng-Yuan Kao, Hediye N Cinar, Raffi V Aroian
Published 2009-12-01

In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasi...

by Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K Nielsen, Raffi V Aroian
Published 2018-05-01

Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum.

by Joseph F Urban, Yan Hu, Melanie M Miller, Ulrike Scheib, Ying Y Yiu, Raffi V Aroian
Published 2013-01-01

Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms.

by Yan Hu, Bin Zhan, Brian Keegan, Ying Y Yiu, Melanie M Miller, Kathryn Jones, Raffi V Aroian
Published 2012-01-01

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes

by Zeynep Mirza, Ernesto R. Soto, Yan Hu, Thanh-Thanh Nguyen, David Koch, Raffi V. Aroian, Gary R. Ostroff
Published 2020-06-01

An extensive comparison of the effect of anthelmintic classes on diverse nematodes.

by Yan Hu, Brian L Ellis, Ying Y Yiu, Melanie M Miller, Joseph F Urban, Linda Z Shi, Raffi V Aroian
Published 2013-01-01

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.

by Chang-Shi Chen, Audrey Bellier, Cheng-Yuan Kao, Ya-Luen Yang, Huan-Da Chen, Ferdinand C O Los, Raffi V Aroian
Published 2010-03-01

The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans.

by Melanie F Kho, Audrey Bellier, Venkatasamy Balasubramani, Yan Hu, Wayne Hsu, Christina Nielsen-LeRoux, Shauna M McGillivray, Victor Nizet, Raffi V Aroian
Published 2011-01-01

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

by Larry J Bischof, Cheng-Yuan Kao, Ferdinand C O Los, Manuel R Gonzalez, Zhouxin Shen, Steven P Briggs, F Gisou van der Goot, Raffi V Aroian
Published 2008-10-01

Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release

by Ernesto R. Soto, Florentina Rus, Hanchen Li, Carli Garceau, Jeffrey Chicca, Mostafa Elfawal, David Gazzola, Martin K. Nielsen, Joseph F. Urban, Raffi V. Aroian, Gary R. Ostroff
Published 2021-05-01

eIF2α confers cellular tolerance to S. aureus α-toxin

by Gisela evon Hoven, Claudia eNeukirch, Sabine eFüser, Maria eBidna Petrivna, Martina eMeyenburg, Amable J. Rivas, Alexey eRyazanov, Randal J. Kaufman, Raffi V. Aroian, Matthias eHusmann
Published 2015-07-01

An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals

by Joseph F. Urban, Jr, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, Raffi V. Aroian
Published 2021-06-01

Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure

by Yan Hu, Thanh-Thanh Nguyen, Alice.C.Y. Lee, Joseph F. Urban, Jr., Melanie M. Miller, Bin Zhan, David J. Koch, Jason B. Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D. Bowman, Gary R. Ostroff, Raffi V. Aroian
Published 2018-08-01

Global functional analyses of cellular responses to pore-forming toxins.

by Cheng-Yuan Kao, Ferdinand C O Los, Danielle L Huffman, Shinichiro Wachi, Nicole Kloft, Matthias Husmann, Valbona Karabrahimi, Jean-Louis Schwartz, Audrey Bellier, Christine Ha, Youn Sagong, Hui Fan, Partho Ghosh, Mindy Hsieh, Chih-Shen Hsu, Li Chen, Raffi V Aroian
Published 2011-03-01

A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep

by John Sanders, Yue Xie, David Gazzola, Hanchen Li, Ambily Abraham, Kelly Flanagan, Florentina Rus, Melanie Miller, Yan Hu, Sierra Guynn, Austin Draper, Sridhar Vakalapudi, Katherine H. Petersson, Dante Zarlenga, Robert W. Li, Joseph F. Urban, Jr., Gary R. Ostroff, Anne Zajac, Raffi V. Aroian
Published 2020-12-01