Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poorly understood. Here, we describe for the fir...

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Bibliographic Details
Main Authors: Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Anna Laemmerer, Patrick Moser, Lisa Gabler, Diana Groza, Christian R. Kowol, Petra Heffeter, Michael Grusch, Walter Berger
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
cancer
drug sequestration
fibroblast growth factor receptor
fluorescence
lysosomes
TKI
Online Access:https://www.mdpi.com/2073-4409/7/12/259

Internet

https://www.mdpi.com/2073-4409/7/12/259

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