Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge

Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge

The development of an influenza vaccine with broad protection and durability remains an attractive idea due to the high mutation rate of the influenza virus. An extracellular domain of Matrix 2 protein (M2e) is among the most attractive target for the universal influenza vaccine owing to its high co...

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Bibliographic Details
Main Authors: Daria Mezhenskaya, Irina Isakova-Sivak, Victoria Matyushenko, Svetlana Donina, Andrey Rekstin, Konstantin Sivak, Kirill Yakovlev, Anastasia Katelnikova, Kirill Kryshen, Valery Makarov, Larisa Rudenko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
universal influenza vaccine
live attenuated influenza vaccine
M2e epitope
ferret model
recombinant vaccine
cross-protection
Online Access:https://www.mdpi.com/1999-4915/13/7/1280

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https://www.mdpi.com/1999-4915/13/7/1280

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