DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

DEB025/Debio 025 (Alisporivir) is a cyclophilin (Cyp)-binding molecule with potent anti-hepatitis C virus (HCV) activity both in vitro and in vivo. It is currently being evaluated in phase II clinical trials. DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for...

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Bibliographic Details
Main Authors: Lotte Coelmont, Xavier Hanoulle, Udayan Chatterji, Carola Berger, Joke Snoeck, Michael Bobardt, Precious Lim, Inge Vliegen, Jan Paeshuyse, Grégoire Vuagniaux, Anne-Mieke Vandamme, Ralf Bartenschlager, Philippe Gallay, Guy Lippens, Johan Neyts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965138?pdf=render

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http://europepmc.org/articles/PMC2965138?pdf=render

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