Cyclophilin Inhibitors: An Emerging Class of Therapeutics for the Treatment of Chronic Hepatitis C Infection

by Philippe Gallay, Sam Hopkins
Published 2012-10-01

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.

by Michael Bobardt, Joseph Kuo, Udayan Chatterji, Norbert Wiedemann, Gregoire Vuagniaux, Philippe Gallay
Published 2020-01-01

Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice.

by Michael Bobardt, Magnus Joakim Hansson, Patrick Mayo, Daren Ure, Robert Foster, Philippe Gallay
Published 2020-01-01

The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice.

by Philippe Gallay, Daren Ure, Michael Bobardt, Udayan Chatterji, James Ou, Daniel Trepanier, Robert Foster
Published 2019-01-01

Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis

by Joseph Kuo, Sonia Simón Serrano, Sonia Simón Serrano, Alvar Grönberg, Ramin Massoumi, Magnus Joakim Hansson, Philippe Gallay
Published 2019-09-01

Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular Carcinoma

by Sonia Simón Serrano, Michele Tavecchio, Alvar Grönberg, Wondossen Sime, Mohamed Jemaà, Steven Moss, Matthew Alan Gregory, Philippe Gallay, Eskil Elmér, Magnus Joakim Hansson, Ramin Massoumi
Published 2021-06-01

Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis

by Sonia Simón Serrano, Alvar Grönberg, Lisa Longato, Krista Rombouts, Joseph Kuo, Matthew Gregory, Steven Moss, Eskil Elmér, Giuseppe Mazza, Philippe Gallay, Massimo Pinzani, Magnus J. Hansson, Ramin Massoumi
Published 2019-11-01

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

by Lotte Coelmont, Xavier Hanoulle, Udayan Chatterji, Carola Berger, Joke Snoeck, Michael Bobardt, Precious Lim, Inge Vliegen, Jan Paeshuyse, Grégoire Vuagniaux, Anne-Mieke Vandamme, Anne-Mieke Vandamme, Ralf Bartenschlager, Philippe Gallay, Guy Lippens, Johan Neyts
Published 2010-10-01