A humanized monoclonal antibody against the endothelial chemokine CCL21 for the diagnosis and treatment of inflammatory bowel disease.

A humanized monoclonal antibody against the endothelial chemokine CCL21 for the diagnosis and treatment of inflammatory bowel disease.

Chemokines are small proteins that promote leukocyte migration during development, infection, and inflammation. We and others isolated the unique chemokine CCL21, a potent chemo-attractant for naïve T-cells, naïve B-cells, and immature dendritic cells. CCL21 has a 37 amino acid carboxy terminal exte...

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Bibliographic Details
Main Authors: Maegan L Capitano, Aruna Jaiswal, Hal E Broxmeyer, Yilianys Pride, Sarah Glover, Fatemah G Amlashi, Austin Kirby, Gayathri Srinivasan, Elizabeth A Williamson, Daniel Mais, Robert Hromas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0252805

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https://doi.org/10.1371/journal.pone.0252805

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