Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-resistant B-precursor Acute Lymphoblastic Leukemia in Mice

Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-resistant B-precursor Acute Lymphoblastic Leukemia in Mice

In high-risk remission B-precursor acute lymphoblastic leukemia (BPL) patients, relapse rates have remained high post-hematopoietic stem cell transplantation (HSCT) even after the use of very intensive total body irradiation (TBI)-based conditioning regimens, especially in patients with a high “mini...

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Bibliographic Details
Main Authors: Fatih M. Uckun, Dorothea E. Myers, Hong Ma, Rebecca Rose, Sanjive Qazi
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:EBioMedicine
Subjects:
Leukemia
Bone marrow transplantation
Total body irradiation
Radiation resistance
Personalized medicine
Precision medicine
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000560

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http://www.sciencedirect.com/science/article/pii/S2352396415000560

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