CD123-Directed Bispecific Antibodies for Targeting MDS Clones and Immunosuppressive Myeloid-Derived Suppressor Cells (MDSC) in High-Risk Adult MDS Patients

by Fatih M. Uckun, Fatih M. Uckun, Justin Watts
Published 2021-09-01

Reducing the Fatality Rate of COVID-19 by Applying Clinical Insights From Immuno-Oncology and Lung Transplantation

by Fatih M. Uckun
Published 2020-05-01

Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma

by Fatih M. Uckun
Published 2021-04-01

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

by Emre Sahin, Cemal Orhan, Fatih M. Uckun, Fatih M. Uckun, Kazim Sahin
Published 2020-10-01

Targeting Solid Tumors With BTK Inhibitors

by Fatih M. Uckun, Taracad Venkatachalam
Published 2021-04-01

Repurposing Anti-Malaria Phytomedicine Artemisinin as a COVID-19 Drug

by Fatih M. Uckun, Saran Saund, Hitesh Windlass, Vuong Trieu
Published 2021-03-01

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superi...

by Fatih M. Uckun, Dorothea E. Myers, Jianjun Cheng, Sanjive Qazi
Published 2015-06-01

Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma

by Fatih M. Uckun, Sanjive Qazi, Taner Demirer, Richard E. Champlin
Published 2019-01-01

A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies

by Fatih M. Uckun, Sanjive Qazi, Hong Ma, Lichen Yin, Jianjun Cheng
Published 2014-12-01

Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Ac...

by Fatih M. Uckun, Fatih M. Uckun, James Carlson, Cemal Orhan, Joy Powell, Natalie M. Pizzimenti, Hendrik van Wyk, Ibrahim H. Ozercan, Michael Volk, Kazim Sahin
Published 2020-11-01

Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-resistant B-precursor Acute Lymphoblastic...

by Fatih M. Uckun, Dorothea E. Myers, Hong Ma, Rebecca Rose, Sanjive Qazi
Published 2015-04-01

Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase.

by Hong Ma, Sanjive Qazi, Zahide Ozer, Jian Zhang, Rita Ishkhanian, Fatih M Uckun
Published 2013-01-01

A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator

by Fatih M. Uckun, Hong Ma, Zahide Ozer, Patricia Goodman, Jian Zhang, Sanjive Qazi
Published 2014-11-01

Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix (RJX)

by Fatih M. Uckun, Cemal Orhan, Joy Powell, Emre Sahin, Ibrahim H. Ozercan, Michael Volk, Kazim Sahin
Published 2021-09-01

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.

by Fatih M Uckun, Hong Ma, Rita Ishkhanian, Martha Arellano, Anoush Shahidzadeh, Amanda Termuhlen, Paul S Gaynon, Sanjive Qazi
Published 2013-01-01

A Phase 1B Clinical Study of Combretastatin A1 Diphosphate (OXi4503) and Cytarabine (ARA-C) in Combination (OXA) for Patients with Relapsed or Refractory Acute Myeloid Leukemia

by Fatih M. Uckun, Christopher R. Cogle, Tara L. Lin, Sanjive Qazi, Vuong N. Trieu, Gary Schiller, Justin M. Watts
Published 2019-12-01

Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL

by Fatih M. Uckun, Lloyd G. Mitchell, Sanjive Qazi, Yang Liu, Nan Zheng, Dorothea E. Myers, Ziyuan Song, Hong Ma, Jianjun Cheng
Published 2015-07-01

A Clinical Phase 1B Study of the CD3xCD123 Bispecific Antibody APVO436 in Patients with Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

by Fatih M. Uckun, Tara L. Lin, Alice S. Mims, Prapti Patel, Cynthia Lee, Anoush Shahidzadeh, Paul J. Shami, Elizabeth Cull, Christopher R. Cogle, Justin Watts
Published 2021-08-01