Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

The extracellular matrix (ECM) plays critical roles in tumor progression and metastasis. However, the contribution of ECM proteins to early metastatic onset in the peritoneal cavity remains unexplored. Here, we suggest a new route of metastasis through the interaction of integrin alpha 2 (ITGA2) wit...

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Bibliographic Details
Main Authors: Yen-Lin Huang, Ching-Yeu Liang, Danilo Ritz, Ricardo Coelho, Dedy Septiadi, Manuela Estermann, Cécile Cumin, Natalie Rimmer, Andreas Schötzau, Mónica Núñez López, André Fedier, Martina Konantz, Tatjana Vlajnic, Diego Calabrese, Claudia Lengerke, Leonor David, Barbara Rothen-Rutishauser, Francis Jacob, Viola Heinzelmann-Schwarz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
integrin alpah 2
Collagen
omentum
Peritoneal metastasis
Cell adhesion
focal adhesion kinase
Online Access:https://elifesciences.org/articles/59442

Internet

https://elifesciences.org/articles/59442

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