Myelin Defects in Niemann–Pick Type C Disease: Mechanisms and Possible Therapeutic Perspectives

Myelin Defects in Niemann–Pick Type C Disease: Mechanisms and Possible Therapeutic Perspectives

Niemann–Pick type C (NPC) disease is a wide-spectrum clinical condition classified as a neurovisceral disorder affecting mainly the liver and the brain. It is caused by mutations in one of two genes, <i>NPC1</i> and <i>NPC2</i>, coding for proteins located in the lysosomes. N...

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Bibliographic Details
Main Authors: Antonietta Bernardo, Chiara De Nuccio, Sergio Visentin, Alberto Martire, Luisa Minghetti, Patrizia Popoli, Antonella Ferrante
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann–Pick type C disease
myelination
oligodendrocytes
cholesterol
mitochondrial impairment
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Online Access:https://www.mdpi.com/1422-0067/22/16/8858

Internet

https://www.mdpi.com/1422-0067/22/16/8858

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