Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.

In the brain, seizures lead to release of large amounts of polyunsaturated fatty acids including arachidonic acid (ARA). ARA is a substrate for three major enzymatic routes of metabolism by cyclooxygenase, lipoxygenase and cytochrome P450 enzymes. These enzymes convert ARA to potent lipid mediators...

Full description

Bibliographic Details
Main Authors: Bora Inceoglu, Dorota Zolkowska, Hyun Ju Yoo, Karen M Wagner, Jun Yang, Edward Hackett, Sung Hee Hwang, Kin Sing Stephen Lee, Michael A Rogawski, Christophe Morisseau, Bruce D Hammock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3862847?pdf=render

Internet

http://europepmc.org/articles/PMC3862847?pdf=render

Similar Items