Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria

Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria

Mercaptopyruvate sulfurtransferase (Mpst) and its homolog thiosulfate sulfurtransferase (Tst = rhodanese) detoxify cyanide to thiocyanate. Mpst is attracting attention as one of the four endogenous hydrogen sulfide (H<sub>2</sub>S)/reactive sulfur species (RSS)-producing enzymes, along w...

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Bibliographic Details
Main Authors: Noriyuki Akahoshi, Tatsuro Minakawa, Masashi Miyashita, Uran Sugiyama, Chihiro Saito, Rintaro Takemoto, Akihiro Honda, Waka Kamichatani, Shotaro Kamata, Yasumi Anan, Isao Ishii
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
crispr/cas9
cystathionine γ-lyase
hydrogen sulfide
mercaptolactate-cysteine disulfiduria
mercaptopyruvate sulfurtransferase
passive systemic anaphylaxis
reactive sulfur species
thiosulfate sulfurtransferase
Online Access:https://www.mdpi.com/1422-0067/21/3/818

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https://www.mdpi.com/1422-0067/21/3/818

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