Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control.

Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control.

Directing stem cell fate requires knowledge of how signaling networks integrate temporally and spatially segregated stimuli. We developed and validated a computational model of signal transducer and activator of transcription-3 (Stat3) pathway kinetics, a signaling network involved in embryonic stem...

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Bibliographic Details
Main Authors: Alborz Mahdavi, Ryan E Davey, Patrick Bhola, Ting Yin, Peter W Zandstra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-07-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1913098?pdf=render

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http://europepmc.org/articles/PMC1913098?pdf=render

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