SAG/ROC-SCFβ-TrCP E3 Ubiquitin Ligase Promotes Pro-Caspase-3 Degradation as a Mechanism of Apoptosis Protection

SAG/ROC-SCFβ-TrCP E3 Ubiquitin Ligase Promotes Pro-Caspase-3 Degradation as a Mechanism of Apoptosis Protection

Skp1-cullin-F-box protein (SCF) is a multicomponent E3 ubiquitin (Ub) ligase that ubiquitinates a number of important biologic molecules such as p27, β-catenin, and lκB for proteasomal degradation, thus regulating cell proliferation and survival. One SCF component, SAG/ROC2/Rbx2/Hrt2, a RING finger...

Full description

Bibliographic Details
Main Authors: Mingjia Tan, Jayme R. Gallegos, Qingyang Gu, Yuanhui Huang, Jun Li, Yetao Jin, Hua Lu, Yi Sun
Format: Article
Language:English
Published: Elsevier 2006-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
SAG
SCF E3 ligase
apoptosis
caspase-3
protein ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606801107

Internet

http://www.sciencedirect.com/science/article/pii/S1476558606801107

Similar Items