The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

The initiating events that promote tau mislocalization and pathology in Alzheimer’s disease (AD) are not well defined, partly because of the lack of endogenous models that recapitulate tau dysfunction. We exposed wild-type neurons to a neuroinflammatory trigger and examined the effect on endogenous...

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Bibliographic Details
Main Authors: Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B. Meeker, Todd J. Cohen
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
deacetylase
excitotoxic
neuroinflammatory
tau
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311038

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http://www.sciencedirect.com/science/article/pii/S2211124717311038

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