Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau pathology through the brain are common hallmarks of tauopathies, including Alzheimer’s disease (AD). Propagation of Tau pathology appears to occur along connected neurons, but whether synaptic contacts between neur...

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Bibliographic Details
Main Authors: Sara Calafate, Arjan Buist, Katarzyna Miskiewicz, Vinoy Vijayan, Guy Daneels, Bart de Strooper, Joris de Wit, Patrik Verstreken, Diederik Moechars
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715004441

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