Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.

Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor growth have been described, therefore targeting PTK...

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Bibliographic Details
Main Authors: Luping Qiu, Kymberly Levine, Ketan S Gajiwala, Ciarán N Cronin, Asako Nagata, Eric Johnson, Michelle Kraus, John Tatlock, Robert Kania, Timothy Foley, Shaoxian Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5991704?pdf=render

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http://europepmc.org/articles/PMC5991704?pdf=render

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